Very little is known about Santiago. Louis encounters Santiago when walking through the city one night. Santiago is showing his mimicking abilities and a mocking, playful attitude. He is also one of the vampires who was housed and preformed at the Théâtre des Vampires. Santiago was later killed by Louis de Pointe du Lac when taking out his revenge for Claudia's death.
In "Interview with the vampire" Santiago is played by Stephen Rea.